Publications


Byrne LC. What's old is new again: Autologous stem cell transplant for AMD. Sci Transl Med. 2017 Apr 26;9(387).

Byrne LC. Rounding up sickle cells with gene therapy. Sci Transl Med. 2017 Mar 15;9(381).

Shen SQ, Myers CA, Hughes AE, Byrne LC, Flannery JG, Corbo JC. Massively parallel cis-regulatory analysis in the mammalian central nervous system. Genome Res. 2016 Feb;26(2):238-55.

Aït-Ali N, Fridlich R, Millet-Puel G, Clérin E, Delalande F, Jaillard C, Blond F, Perrocheau L, Reichman S, Byrne LC, Olivier-Bandini A, Bellalou J, Moyse E, Bouillaud F, Nicol X, Dalkara D, van Dorsselaer A, Sahel JA, Léveillard T. Rod-derived cone viability factor promotes cone survival by stimulating aerobic glycolysis. Cell. 2015 May 7;161(4):817-32. 
Comment: Krol J, Roska B. Rods Feed Cones to Keep them Alive. Cell. 2015 May 7;161(4).
 
Xue Y, Shen SQ, Jui J, Rupp AC, Byrne LC, Hattar S, Flannery JG, Corbo JC, Kefalov VJ. CRALBP supports the mammalian retinal visual cycle and cone vision. J Clin Invest. 2015 Feb;125(2):727-38.

Byrne LC, Lee T, Flannery JG, Dalkara D. The expression pattern of systemically injected AAV9 in the developing mouse retina is determined by age. Mol Ther. 2015 Feb;23(2):290-6.

Byrne LC, Dalkara D, Luna G, Fisher SK, Clérin E, Sahel JA, Léveillard T, Flannery JG. Viral-mediated RdCVF and RdCVFL expression protects cone and rod photoreceptors in retinal degeneration. J Clin Invest. 2015 Jan;1 25(1):105-16.

Byrne LC, Oztürk BE, Lee T, Fortuny C, Visel M, Dalkara D, Schaffer DV, Flannery JG. Retinoschisin gene therapy in photoreceptors, Müller glia or all retinal cells in the Rs1h-/- mouse. Gene Ther. 2014 Jun;21(6):585-92.

Day TP/Byrne LC (equally contributing co-first author), Schaffer DV, Flannery JG. Advances in AAV Vector Development for Gene Therapy in the Retina. Adv Exp Med Biol. 2014;801:687-93.

Byrne LC, Khalid F, Lee T, Zin EA, Greenberg KP, Visel M, Schaffer DV, Flannery JG. AAV-mediated, optogenetic ablation of Müller Glia leads to structural and functional changes in the mouse retina. PLoS One. 2013 Sep 27;8(9):e76075.

Dalkara D/Byrne LC (equally contributing co-first author), Klimczak RR, Visel M, Yin L, Merigan WH, Flannery JG, Schaffer DV. In vivo-directed evolution of a new adeno-associated virus for therapeutic outer retinal gene delivery from the vitreous. Sci Transl Med. 2013 Jun 12;5(189):189ra76. 

Dalkara D, Byrne LC, Lee T, Hoffmann NV, Schaffer DV, Flannery JG. Enhanced gene delivery to the retina through systemic administration of tyrosine mutated AAV9. Gene Ther. 2012 Feb;19(2):176-81.

Okajima K, Warman ML, Byrne LC, and Kerr DS. Somatic mosaicism in a male with an exon skipping mutation in PDHA1 of the pyruvate dehydrogenase complex results in a milder phenotype. Mol Genet Metab. 2006 Feb; 87(2):162-8.

Capaldi RA, Murray J, Byrne L, Janes MS, Marusich MF. Immunological approaches to the characterization and diagnosis of mitochondrial disease. Mitochondrian. 2004 Sep; 4(5-6): 417-26.

Byrne LC, Zhou Z, Tryggvason K, Hökfelt T, Fetissov, SO. Altered NPY and AgRP in membrane type-1 matrix metalloproteinase-deficient mice. NeuroReport. 2004 March 1; 15(3): 569-574.

Fetissov SO, Byrne LC, Hassani H, Ernfors P, Hökfelt T. Characterization of neuropeptide Y Y2 and Y5 receptor expression in the mouse hypothalamus. J Comp Neurol. 2004 Mar 8;470(3):256-65.

Fetissov SO, Xu ZQ, Byrne LC, Hassani H, Ernfors P, Hökfelt T. Neuropeptide y targets in the hypothalamus: nitric oxide synthesizing neurons express Y1 receptor. J Neuroendocrinol. 2003 Aug;15(8):754-60.